Adjuvant chemotherapy after concurrent chemoradiation for locally advanced cervical cancer
نویسندگان
چکیده
منابع مشابه
Neoadjuvant chemotherapy for locally advanced cervical cancer
Neoadjuvant chemotherapy followed by surgery (NCS) has not been fully evaluated clinically. Currently, the main regimen of neoadjuvant chemotherapy (NAC) used in NCS includes cisplatin. The antitumor effects of NAC reduce lymph node metastasis and the tumor diameter in patients prior to surgery, and this can reduce the number of high risk patients who require postoperative radiation therapy. Ma...
متن کاملPhase II Study of Consolidation Chemotherapy after Adjuvant or Primary Concurrent Chemoradiation Using Paclitaxel and Carboplatin to Treat High-Risk Early-Stage or Locally Advanced Cervical Cancer
PURPOSE This study investigated the efficacy and toxicity associated with consolidation chemotherapy using paclitaxel and carboplatin after concurrent chemoradiation (CCR) in cervical cancer patients. MATERIALS AND METHODS From a total of 37 patients, 19 with International Federation of Gynecology and Obstetrics (FIGO) stage IB1-IIA cervical cancer (group 1) underwent surgery followed by cons...
متن کاملConcurrent chemoradiation with weekly gemcitabine and cisplatin for locally advanced cervical cancer.
BACKGROUND For more than 80 years, the standard treatment of locally advanced cervical cancer was radiotherapy. However, based on several phase III randomized clinical trials in the past decade, concurrent cisplatin-based chemoradiotherapy is the current standard for this disease. Gemcitabine has potent radiosensitizing properties in preclinical and clinical trials, so it can be utilized simult...
متن کاملConcurrent Chemoradiation for Cervical Cancer.
The current practice of treating cervical cancer with surgery or radiation alone has been challenged by the recent information from the National Cancer Institute regarding concurrent chemoradiation for cervical cancer. Results from each of five randomized phase III trials show an overall survival advantage of 30% — plus acceptable toxicity — for cisplatin-based therapy given concurrently with r...
متن کاملPrognostic significance of pathological response after neoadjuvant chemotherapy or chemoradiation for locally advanced cervical carcinoma
BACKGROUND Cisplatin-based chemoradiation is the standard of care for locally advanced cervical cancer patients; however, neoadjuvant modalities are currently being tested. Neoadjuvant studies in several tumor types have underscored the prognostic significance of pathological response for survival; however there is a paucity of studies in cervical cancer investigating this issue. METHODS Four...
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ژورنال
عنوان ژورنال: Cochrane Database of Systematic Reviews
سال: 2014
ISSN: 1465-1858
DOI: 10.1002/14651858.cd010401.pub2